Table 3.

Reported target TFs in improving S. cerevisiae resistance to stress factors

Target TF	Function	Regulation	Stress factor	Refs.
Ace2p	Activate transcription of genes encoding chitinases and glucanases	Overexpression	Acetic acid and furfural	[43]
Haa1p	Weak acid-responsive transcriptional activator	Overexpression	Organic acids	[130–132]
Hap4p	Transcriptional activator and global regulator of respiratory gene expression	Overexpression	Acetic acid, formic acid, and furfural	[27]
Msn2/4p	Stress-responsive transcriptional activator	Overexpression	Acetic acid, furfural, oxidative stress, and osmotic shock	[133–135]
Ppr1p	Zinc finger transcription factor	Overexpression	Acetic acid and ROS	[106]
Sfp1p	Regulates transcription of ribosomal protein and biogenesis genes	Overexpression	Acetic acid and furfural	[43]
Skn7p	Nuclear response regulator and transcription factor	Overexpression	Osmotic and oxidative	[136–138]
Tye7p	contribute to glycolytic genes activation	Overexpression	Acetic acid and furfural	[27]
Yap1p	Basic leucine zipper (bZIP) transcription factor	Overexpression	Oxidative stress, furfural, HMF, and vanillin	[67, 139, 140]
Yrr1p	Zn2-Cys6 zinc-finger transcription factor	Deletion	Vanillin	[40]