TABLE 5.
Logistic regression analysis of BARD1 exon genotype and breast cancer susceptibility
| Polymorphism | β | SE (β) | Wals | p | OR | 95% CI |
|---|---|---|---|---|---|---|
| rs1048108 | ||||||
| CC | 1.000 | |||||
| CT | 0.182 | 0.313 | 0.339 | 0.561 | 1.200 | 0.650–2.215 |
| TT | −0.135 | 0.452 | 0.089 | 0.766 | 0.874 | 0.360–2.120 |
| CT+TT | 0.105 | 0.296 | 0.125 | 0.724 | 1.110 | 0.621–1.984 |
| rs28997575 | ||||||
| Wild‐type | 1.000 | |||||
| Mutation | 1.401 | 0.485 | 8.349 | 0.004 | 4.059 | 1.569–10.498 |
| rs2229571 | ||||||
| GG | 1.000 | |||||
| GC | −1.081 | 0.351 | 9.514 | 0.002 | 0.339 | 0.171–0.674 |
| CC | −1.631 | 0.412 | 15.660 | 0.000 | 0.196 | 0.087–0.439 |
| GC+CC | −1.290 | 0.327 | 15.558 | 0.000 | 0.275 | 0.145–0.523 |
| rs2070094 | ||||||
| GG | 1.000 | |||||
| GA | −0.027 | 0.312 | 0.008 | 0.931 | 0.973 | 0.528–1.794 |
| AA | 0.236 | 0.442 | 0.258 | 0.593 | 1.266 | 0.532–3.011 |
| GA+AA | 0.034 | 0.293 | 0.014 | 0.907 | 1.035 | 0.583–1.836 |
| rs3738888 | ||||||
| CC | 1.000 | |||||
| CT | −0.423 | 0.693 | 0.372 | 0.542 | 1.526 | 0.392–5.936 |
Binary Loostic regression was used to analyze the genotype of the BARD1 gene exon region, breast cancer susceptibility, aOR1, and confidence interval (95% CI). Two‐sided test with p < 0.05 was considered statistically significant.