TABLE 6.
Logistic regression analysis of the BARD1 exon genotype and breast cancer susceptibility after adjusting for family history
| Polymorphism | β | SE (β) | Wals | p | aOR1 | 95% CI |
|---|---|---|---|---|---|---|
| rs1048108 | ||||||
| CC | 1.000 | |||||
| CT | 0.032 | 0.325 | 0.977 | 0.323 | 1.379 | 0.729–2.610 |
| TT | −0.004 | 0.461 | 0.000 | 0.993 | 0.996 | 0.404–2.45 |
| CT+TT | 0.241 | 0.309 | 0.610 | 0.435 | 1.273 | 0.695–2.332 |
| rs28997575 | ||||||
| Wild‐type | 1.000 | |||||
| Mutation | 1.246 | 0.501 | 6.184 | 0.013 | 3.475 | 1.302–9.276 |
| rs2229571 | ||||||
| GG | 1.000 | |||||
| GC | −1.294 | 0.367 | 12.457 | 0.000 | 0.274 | 0.134–0.562 |
| CC | −1.758 | 0.420 | 17.556 | 0.000 | 0.172 | 0.076–0.392 |
| GC+CC | −1.480 | 0.340 | 18.956 | 0.000 | 0.228 | 0.117–0.443 |
| rs2070094 | ||||||
| GG | 1.000 | |||||
| GA | −0.182 | 0.328 | 0.307 | 0.580 | 0.834 | 0.438–1.586 |
| AA | 0.043 | 0.461 | 0.009 | 0.926 | 1.043 | 0.423–2.577 |
| GA+AA | −0.132 | 0.311 | 0.179 | 0.672 | 0.877 | 0.477–1.612 |
| rs3738888 | ||||||
| CC | 1.000 | |||||
| CT | −0.049 | 0.753 | 0.004 | 0.948 | 0.952 | 0.218–4.167 |
The adjusted variable was family history. After adjusting for family history, binary Logistic regression was used to analyze the BARD1 exon genotype and breast cancer susceptibility as well as aOR1 and confidence interval (95% CI). Two‐sided test with p < 0.05 was statistically significant.