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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Nat Struct Mol Biol. 2021 Mar 25;28(4):365–372. doi: 10.1038/s41594-021-00565-x

Extended Data Fig. 2. Sigmoidal and exponential fits of PrPSc measurements obtained here.

Extended Data Fig. 2

Data as shown in the main text (a-d), as well as the data obtained without PK digestion (e-g), fitted to both a sigmoidal function (solid line) and a simple exponential (dotted line). All data points (filled and open circles) are used in the sigmoidal fits, only pre-plateau data points (filled circles) are used in the exponential fits. The data include samples from different mice as well as technical repeats of the ELISA measurements (3–4 at each timepoint). Data behind graphs are available as Source Data.