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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Nat Microbiol. 2021 Dec 14;7(1):108–119. doi: 10.1038/s41564-021-01019-2

Extended Data Fig. 1. SDSI core sequence in silico validation.

Extended Data Fig. 1

We surveyed the core SDSI sequences by BLASTn to identify significant homology. a, Significant homology between SDSIs and anything in the NCBI database outside the domain archaea was identified and the SDSI and genus were plotted if identity (y-axis) was greater than 90% and query cover (x-axis) was greater than 50 bps. b, For each SDSI, we identified and plotted (see color scale) the maximum alignment score for a significant homology to human (taxid:9606) and viral (taxid:10239) sequences in the NCBI database. We also identified and plotted the alignment score for each pairwise combination of SDSIs.