Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 22;12(1):2670–2702. doi: 10.1080/21505594.2021.1982373

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — HSV cell cycle. (1) HSV glycoprotein D or B interact with specific cellular receptors leading to fusion at the plasma membrane (2) of following endocytosis (not shown in this figure). Upon fusion, the capsid is released to the cytoplasm with some attached tegument proteins, while other tegument proteins like VP16 separate from the capsid. (3) The capsid travels to the cell nucleus using microtubuli due to the interaction between UL36 and motor proteins. The linear DNA enters the nucleus . (4) The tegument protein VP16 enters the nucleus together with HCF-1 and Oct-1 and starts transcription of IE genes. (5) The IE genes are translated and participate in the transcription of E genes (6), which take part in the replication of the viral genome (8). Once there are sufficient copies of viral genomes, the products of the L genes facilitate DNA encapsidation (11). The mature, DNA containing capsids (C capsids) leave the nucleus through an envelopment-deenvelopment process and acquire tegument and envelope (not shown) prior to cellular egress (14)