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. 2022 Feb 21;9:790917. doi: 10.3389/fcvm.2022.790917

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Copyright © 2022 Xie, Liu, Wei, Ye, Ma, Lu, Tan, Li, Wang, Zhao, Lu, Li, Chen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A 17-year-old male presented with chest tightness, shortness of breath, and syncope and was genetically diagnosed with Danon disease (mutation site: c.35C > A). (A) f-QRS was found in 12 leads. Notched R/S patterns (single red arrows) were found in the I, II, aVL, and V1–V6 leads. The fragmented QRS pattern was found in III and aVF leads (double red arrows), and the total f-QRS score was 15. (B) Four-chamber view and (C) short-axis view of LGE images on CMR showed the extensive fibrosis/scarring in the lateral wall of LV and patchy fibrosis in the septum (orange arrows). Global LV LGE% was 36.7%. LGE, late gadolinium enhancement.