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Steady-state pharmacokinetic profile of ceftolozane for three dosage regimens in patients with creatinine clearance of 29 mL/min. Simulated dosage regimens are as follows: 250 mg q8h as a 1-h infusion (top), 1,000 mg q24h as a 2-h infusion (center), 1,000 mg q24h as a 4-h infusion time (bottom). The five lines represent the 5th, 25th, 50th (median), 75th, and 95th percentiles of simulated concentrations. The gray areas are the 95% confidence intervals around percentiles.
