TABLE 2.

Comparison of CAB LA PK parameters after the final injection between adult Chinese male participants and non-Asian male participants in HPTN 077^a

PK parameterb	Chinese male participants in present study (n = 44)	Non-Asian male participants in HPTN 077 (n = 18)c
AUC0-t (h · μg/mL)	143 (127–162)d	163
Cmax (μg/mL)	3.73 (3.11–4.48)	3.82
Trough concentration (μg/mL)	1.58 (1.39–1.80)d	1.68
t1/2 (days)	47.0 (38.4–57.6)e	45.3
Estimated time to LLOQ, median (range) [IQR] (wks)	48.7 (16.5–251.0) [31.9–71.5]	43.7 (20.4–152.5) [31.1–66.6]

^aAUC_0-t, area under the plasma concentration-time curve over the dosing interval; CAB, cabotegravir; CI, confidence interval; C_max, maximum observed concentration; LA, long-acting; LLOQ, lower limit of quantitation; PK, pharmacokinetic(s); t_1/2, terminal half-life. All values calculated based on the final injection.

^bData presents geometric mean (95% CI) unless otherwise noted.

^cOnly published data for non-Asian male participants in HPTN 077 are listed. Source data are unavailable; therefore, some 95% CIs are unavailable (30, 36).

^dn = 43.

^en = 41.