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Genome-wide mutagenesis in antibiotic persisters. (A) Whole-genome sequencing analysis of resistant colonies from the persisters of M. smegmatis mc2155. The y axis corresponds to changes in the genome compared to the parental, untreated M. smegmatis mc2155 strain. Isolates 1 to 5 were obtained by streptomycin selection, while isolates 8 to 14 were obtained by ciprofloxacin selection. WT, wild type. (B) Base changes and corresponding positions in the genomes of all the resistant colonies.
