TABLE 1.
Alterations in gyrA and parC genes in clinical isolates of E. faceium
| ATCC strain | MIC (μg/ml)a
|
Amino acid (codon) at positionb
|
|||
|---|---|---|---|---|---|
| CIP | TRV | GyrA
|
ParC, 80 | ||
| 83 | 87 | ||||
| 19434 | 4 | 1 | Ser (AGT) | Glu (GAG) | Ser (AGC) |
| 3797 | 1 | 0.125 | |||
| 216 | 8 | 4 | |||
| 214 | 32 | 8 | Lys (AAG) | Ile (ATC) | |
| 211 | 32 | 8 | Lys (AAG) | Ile (ATC) | |
| 209 | 32 | 16 | Lys (AAG) | Ile (ATC) | |
| 210 | 256 | 8 | Lys (AAG) | Ile (ATC) | |
| 3784 | >256 | 4 | Lys (AAG) | Ile (ATC) | |
| 208 | 64 | 16 | Arg (CGT) | Ile (ATC) | |
| 221 | 256 | 32 | Ile (ATT) | Ile (ATC) | |
| 215 | 256 | 8 | Tyr (TAT) | Ile (ATC) | |
| 213 | >256 | 16 | Tyr (TAT) | Ile (ATC) | |
| 212 | >256 | 32 | Tyr (TAT) | Ile (ATC) | |
a
CIP, ciprofloxacin; TRV, trovafloxacin.
b
Positions correspond to E. coli. For those strains with no amino acid shown, the codon is identical to that of the type strain.