TABLE 2.
Acquired antimicrobial resistance genes in genomes of K. oxytoca complex (n = 588)
| Antimicrobial type | Acquired antimicrobial resistance gene(s)a |
|---|---|
| Carbapenems | blaGES-5, blaIMP-4, -13, -29, -38, blaKPC-2, -3, blaNDM-1, -4, -5, blaOXA-48, -181, blaVIM-1 |
| Other β-lactamsb | blaACC-1, blaCARB-2, -12, blaCMY-6, blaCTX-M-1, -3, -8, -14, -15, -62, blaDHA-1, blaFOX-5, blaLAP-2, blaOXA-1, -2, -9, -10, -101, blaSCO-1, blaSFO-1, blaSHV-2, -5, -7, -12, -14, -30, blaTEM-1, -3, -26, -116, blaTLA-3 |
| Colistin | mcr-9 |
| Aminoglycosides | aac(2′)-IIa, aac(3)-Ia, -IId, -IIe, -IIg, -IVa, aac(6′)-30, -Ib, -Ib′, -Ib3, -Ib4, -Ib-cr, -Ib-cr5, -IIa, -IIc, aadA1, aadA2, aadA4, aadA5, aadA10, aadA11, aadA13, aadA16, ant(2″)-Ia, aph(3′)-Ia, -IIa, -VI, -XV, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, aphA16, armA, rmtC, sat2 |
| Quinolones | qnrA1, qnrB1, qnrB2, qnrB4, qnrB6, qnrB19, qnrS1 |
| Sulfonamides | sul1, sul2, sul3 |
| Trimethoprim | dfrA1, dfrA3b, dfrA10, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, dfrA21, dfrA27, dfrA32, dfrB1 |
| Chloramphenicol | catA1, catA2, catB2, catB3, catB8, catB11, cmlA1, cmlA4, cmlA5, cmlA10, cmx, floR |
| Rifampicin | arr-2, arr-3 |
| Tetracyclines | tet(A), tet(B), tet(C), tet(D), tet(M), tet(34), tet(39) |
| Macrolides | ere(A), mph(A), mph(E), msr(E) |
a
Resistance genes that have not been reported in the literature (1) but are identified in genomes available in the NCBI database are underlined (see Data Set S2).
b
All strains of K. oxytoca complex also have intrinsic blaOXY genes.