FIG 1.

Comparison of individual GFR measurements between treatment groups and across dosing days. The majority of the rats experienced a decline in glomerular filtration rate (GFR) after the first dose of study treatment was given on day 1. Rats in the vancomycin (VAN) + saline (blue) group showed progressive functional decline over the study days, while rats in all other groups recovered their GFR to baseline levels by day 4. Individual rats are depicted by each data point. B.W., body weight; TZP, piperacillin-tazobactam.