TABLE 3.

Final E_max model parameters and fAUC/MIC ratios (of the trimethoprim component) required for stasis and 1-log₁₀ and 2-log₁₀ CFU reductions for S. maltophilia and E. coli^a

Parameter	S. maltophilia	E. coli
Model parameters
Imax	1.16	6.63
IC50	83.5	65.8
E0	1.57	2.05
Gamma	1.47	1.66
PD threshold (fAUC/MIC ratio [of the  trimethoprim component])
Stasis	NC	40.7
1-log10 CFU reduction	NC	59.9
2-log10 CFU reduction	NC	86.3

^aI_max, maximum effect (difference between the minimum and maximum observed CFU); IC₅₀, inhibitory concentration required for 50% of the maximum effect; E₀, maximum observed CFU; Gamma, slope constant; PD, pharmacodynamic; NC, not able to be calculated.