De Ceulaer 1982.

Methods	Randomization with a random number tables with a block size of 2; no allocation concealment
Participants	25 women from an adult‐sickle cell clinic (ages 20 to 41). Inclusion criteria: diagnosed with SS disease and using a reliable, non‐steroid contraceptive.
Interventions	Women were randomized to depo‐medroxyprogesterone acetate or an intramuscular saline placebo injection. After three 3‐month intervals of treatment, a 6‐month washout period was implemented. After the washout, patients received the alternative treatment at three 3‐month intervals.
Outcomes	Frequency and severity of bone pain.
Notes	2 participants were lost to follow up.