Fig 1. SPIRIT schedule of enrolment and assessments.

AEs: Adverse Events, GAD-7: Generalised Anxiety Disorder 7-item Scale, ISI: Insomnia Severity Index Scale, MSQ: Migraine Specific Quality of Life Questionnaire, PHQ-9: Patient Health Questionnaire-9, T0: Timepoint 0, T1: Timepoint 1, T2: Timepoint 2, T3: Timepoint 3.