Table 2.

Seminal plasma CoQ10, oxidative stress markers, and sperm DNA fragmentation levels in fertile and infertile men before and after administration of CoQ10 and Centrum

Variable	Fertile control	Patient before CoQ10	Patient after CoQ10	Patient before Centrum	Patient after Centrum
CoQ10 level (ng/mL)	56.2±38.5	41.6±29.8d)	76.9±26.3b),e)	38.9±27.6d)	40.2±28.1d),g)
ROS (×104  RLU/min/20 million spermatozoa	0.07±0.03	3.52±1.29e)	2.68±1.31c),e)	2.8±0.96e)	2.08±1.04c),e),f)
TAC (mmol/L)	1.12±0.21	0.73±0.36d)	0.92±0.4b),d)	0.56±0.24d)	0.73±0.3c),d),f)
Catalase (U/mL)	12.45±2.49	8.42±2.21e)	9.8±2.06b),e)	6.72±1.75e)	7.8±1.4b),e),g)
Sperm DNA fragmentation (%)	13.2±3.8	35.2±6.4e)	32.1±7.9a),e)	28.3±5.1e)	25.7±4.1b),e),g)

CoQ10, coenzyme Q10; ROS, reactive oxygen species; TAC, total antioxidant capacity; FDR, false discovery rate.

^a)vs. patients before CoQ10, FDR p<0.05;

^b)vs. patients before CoQ10, FDR p<0.01;

^c)vs. patients before CoQ10, FDR p<0.001;

^d)vs. fertile control group, FDR p<0.01;

^e)vs. fertile control group, FDR p<0.001;

^f)vs. patients after CoQ10, FDR p<0.01;

^g)vs. patients after CoQ10, FDR p<0.001.