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. 2022 Feb 28;60(4):42. doi: 10.3892/ijo.2022.5332

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Potential immune risks associated with the application of PD-1 antibodies to treat patients with cancer complicated with a severe COVID-19. Administration of PD-1 antibodies to patients with cancer and severe COVID-19 for an antitumor therapy may result in increased attack against the host cells harboring the viral components due to the activated immune system and even initiate the cytokine storm, thereby promoting inflammation and lung toxicity. COVID-19, corona virus disease 2019; SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2; PD-1, Programmed death-1.