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. 2022 Feb 28;60(4):42. doi: 10.3892/ijo.2022.5332

Figure 6.

Figure 6

Anti-tumor mechanisms of oncolytic viruses. The mechanisms underlying the anti-tumor effect of oncolytic viruses involve: (A) Direct tumor lysis; (B) regulation of tumor immune microenvironment; (C) activation of CD8+ T cells; (D) TIL recruitment; (E) promoting immunogenic cell death; (F) inhibition of tumor angiogenesis; (G) enhanced anti-tumor effect of immune checkpoint inhibitors. TIL, tumor infiltrating lymphocyte.