. 2022 Mar 15;11:e74065. doi: 10.7554/eLife.74065

Table 2. Cross-sectional correlations between leukocyte populations and amyotrophic lateral sclerosis (ALS) Functional Rating Scale-revised (ALSFRS-R) score and disease progression rate, a cohort study of 288 ALS patients in Stockholm, Sweden^*.

Cell type	ALSFRS-R			Progression rate
Cell type	Coefficient	p value	FDR	Coefficient	p value	FDR
Leukocyte (10⁹/l)	−2.80	4.0E−03	0.01	0.02	0.74	0.74
Neutrophil (10⁹/l)	−3.10	1.0E−03	4.0E−03	0.05	0.33	0.67
Lymphocyte (10⁹/l)	1.48	0.15	0.15	−0.08	0.32	0.67
Monocyte (10⁹/l)	−2.75	2.0E−03	4.0E−03	−0.03	0.52	0.69

Bold values denote statistical significance of p < 0.05.

Generalized estimating equation model was applied to derive the coefficient estimates and p values, with adjustment for age at diagnosis and sex. ALSFRS-R score ranges from 0 to 48, with higher score showing better motor function status. Progression rate indicates the decline of motor function per month.

FDR: false discovery rate.

Table 2. Cross-sectional correlations between leukocyte populations and amyotrophic lateral sclerosis (ALS) Functional Rating Scale-revised (ALSFRS-R) score and disease progression rate, a cohort study of 288 ALS patients in Stockholm, Sweden*.

Table 2. Cross-sectional correlations between leukocyte populations and amyotrophic lateral sclerosis (ALS) Functional Rating Scale-revised (ALSFRS-R) score and disease progression rate, a cohort study of 288 ALS patients in Stockholm, Sweden^*.