Table 3. Associations between longitudinal changes in cell measures and longitudinal changes in Amyotrophic Lateral Sclerosis Functional Rating Scale – revised (ALSFRS-R) score, a cohort study of 288 patients with ALS in Stockholm, Sweden†.
| Cell type | Unadjusted | Adjusted* | ||
|---|---|---|---|---|
| Coefficient | p value | Coefficient | p value | |
| Leukocyte (109/l) | −5.72 | 0.010 | −5.41 | 0.012 |
| Neutrophil (109/l) | −4.05 | 0.020 | −3.85 | 0.023 |
| Lymphocyte (109/l) | −0.49 | 0.839 | −0.22 | 0.925 |
| Monocyte (109/l) | −12.90 | 0.001 | −12.14 | 0.001 |
Bold values denote statistical significance of p < 0.05.
*
Adjusted for age at diagnosis and sex.
†
Generalized estimating equation model was applied to derive the coefficient estimates and p values, per unit change of log-transformed leukocyte counts.