Table 6. Efficiency of 68Ga-DOTA-TATE PET/CT in differential diagnosis of PCC and PGL using subgroup-specific optimal cutoff values.
| Subgroups | Sensitivity | Specificity | Accuracy | PPV | NPV |
|---|---|---|---|---|---|
| PCC | |||||
| SUVR | 86.4% (19/22) | 92.9% (13/14) | 88.9% (32/36) | 95.0% (19/20) | 81.2% (13/16) |
| KS | 90.9% (20/22) | 78.6% (11/14) | 86.1% (31/36) | 87.0% (20/23) | 84.6% (11/13) |
| PGL | |||||
| SUVR | 87.5% (14/16) | 100.0% (7/7) | 90.1% (20/23) | 93.3% (14/15) | 75.0% (6/8) |
| KS | 100.0% (16/16) | 71.4% (5/7) | 91.3% (21/23) | 88.9% (16/18) | 100.0% (5/5) |
68Ga-DOTA-TATE, 68Ga-DOTA(0)-Tyr(3)-octreotate; PET/CT, positron emission tomography/computed tomography; PCC, pheochromocytoma; PGL, paraganglioma; PPV, positive predictive value; NPV, negative predictive value; SUVR, ratio between the SUVmax of the lesion and the SUVmean of the liver; SUVmax, maximal standardized uptake value; SUVmean, mean standardized uptake value; KS, Krenning score.