TABLE 1.
Baseline characteristics across OGTT-glucose phenotypes among Latino youth (n = 48)
| 1-h Glucose |
Glucose response curve |
Time to glucose peak |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | 1-h glucose < 155 (n = 30) | 1-h glucose ≥ 155 (n = 18) | p value | Biphasic (n = 9) | Monophasic (n = 39) | p value | Early peak (n = 20) | Late peak (n = 28) | p value |
| Age, years | 15.3 ± 1.0 | 15.4 ± 1.0 | 0.779 | 15.2 ± 1.1 | 15.4 ± 1.0 | 0.665 | 15.2 ± 1.1 | 15.5 ± 0.9 | 0.428 |
| Female, N (%) | 20 (66.7%) | 7 (38.9%) | 0.060 | 6 (66.7%) | 21 (53.8%) | 0.485 | 11 (55.0%) | 16 (57.1%) | 0.762 |
| Prediabetes, N (%) | 2 (22.2%) | 11 (39.3%) | 0.716 | 5 (16.7%) | 8 (44.4%) | 0.040 | 3 (15.0%) | 10 (35.7%) | 0.111 |
| Family history, N (%) | 13 (43.3%) | 5 (27.8%) | 0.281 | 3 (33.3%) | 15 (38.5%) | 0.775 | 7 (35.0%) | 11 (65.0%) | 0.883 |
| PDS | 2.7 ± 0.5 | 2.6 ± 0.4 | 0.418 | 2.8 ± 0.5 | 2.6 ± 0.5 | 0.346 | 2.7 ± 0.5 | 2.7 ± 0.5 | 0.915 |
| BMI, kg/m2 | 34.0 ± 4.9 | 35.5 ± 4.6 | 0.318 | 33.0 ± 2.7 | 34.9 ± 5.1 | 0.271 | 35.5 ± 4.3 | 33.9 ± 5.0 | 0.247 |
| BMI% | 98.0 ± 1.5 | 98.6 ± 0.9 | 0.071 | 97.9 ± 1.4 | 98.3 ± 1.4 | 0.459 | 98.6 ± 0.9 | 97.9 ± 1.6 | 0.083 |
| WC, cm | 106.9 ± 10.4 | 111.7 ± 13.7 | 0.181 | 106.4 ± 7.0 | 109.3 ± 12.7 | 0.520 | 112.3 ± 11.5 | 106.2 ± 11.6 | 0.076 |
| G0, mg/dl | 91.8 ± 5.4 | 94.7 ± 6.8 | 0.104 | 92.5 ± 7.2 | 93.0 ± 5.8 | 0.844 | 94.6 ± 4.3 | 91.6 ± 6.8 | 0.091 |
| G120, mg/dl | 114.7 ± 17.7 | 132.3 ± 20.7 | 0.003 | 117.3 ± 17.5 | 122.2 ± 21.3 | 0.528 | 112.3 ± 19.4 | 127.7 ± 19.1 | 0.009 |
| HOMA-IR | 4.9 ± 2.6 | 6.0 ± 3.1 | 0.161 | 5.1 ± 2.8 | 5.4 ± 2.8 | 0.773 | 5.9 ±2.9 | 4.9 ± 2.7 | 0.223 |
| WBISI | 2.1 ± 1.2 | 1.3 ± 0.6 | 0.012 | 2.0 ± 1.2 | 1.7 ± 1.0 | 0.524 | 1.7 ± 1.0 | 1.8 ± 1.1 | 0.737 |
| oDI | 8.7 ± 5.5 | 3.2 ± 1.2 | <0.001 | 11.2 ± 5.6 | 5.6 ± 3.6 | 0.002 | 6.9 ± 3.5 | 6.5 ± 6.1 | 0.832 |
Note: Data presented as Mean ± SD.
Abbreviations: G0, fasting glucose; G120, 2-h glucose during OGTT; HOMA-IR, homeostatic model assessment of insulin resistance; oDI, oral disposition index; PDS, pubertal development scale; WBISI, whole-body insulin sensitivity index; WC, waist circumference.