Table 4:

Oxidative stress enriched pathways for NRF1 and ID3 target genes

GO ID	GO Description	p-value	Genes
33554	Cellular response to stress	0.0000000001	MDC1, MAPKBP1, PGAP2, CLPB, CCNH, NUDT1, SMC6, SMC3, KAT5, CHEK2, LONP1, FBXO6, EPC2, EIF2A, TIPIN, NSMCE2, SLC11A2, RECQL, ATG10, REV1, SETMAR, CSNK1D, ESCO2, ATG13, MAPK8IP3, ATG12, NEIL2, MAP1B, DNA2, NEIL1, TRIB1, ATF6, ASF1A, ATF4, DHX9, EPAS1, XPA, XPC, BRCC3, PRDX5, BRIP1, NUAK2, NTHL1, PRDX1, HMOX1, SCAP, SFN, APOE, TP53BP1, ATG5, BARD1, TRAP1, JUN, XRCC6, XRCC4, XRCC5, GADD45A, EIF2AK1, INTS3, XRCC2, PLK1, XRCC3, EIF2AK4, PRDX6, GADD45G, TDP2, TDP1, ATM, RAD18, TP73, ATR, BTG2, SMG1, FEN1, MRPS11, OGG1, CTSV, AATF, HERPUD1, ING4, NIPBL, CHAF1A, UIMC1, REV3L, JAK2, IKBKE, CTSD, MAP4K1, SREBF1, MRPS26, PARP3, PARP4, DBNL, MINK1, KIF22, BAZ1B, SIRT1, DDB2, RNF168, RAD51B, KIN, MRPS9, CEP63, MDFI, CHST3, SP100, MRPS35, FAM129A, DERL1, TYMS, FGD4, WRN, PAK1, SLX4, RPS3, PMS2, RAD54L, STX3, ZSWIM7, APBB1, MAP4K5, PMS1, MAP4K3, MBD4, MAP3K1, ATAD5, OSM, RPA1, APEX2, MRE11A, RPA2, GTF2H1, MLH1, APTX, GTF2H5, HIPK2, HINFP, XAB2, TFAP4, NEDD4, RFWD3, RPA3, PKN1, TRIP13, SIPA1, NEK11, DCLRE1C, MPG, MUM1, FGF1, EME1, PTTG1, EME2, CDH1, SESN1, EP300, NBN, FADS1, MAP3K4, MAP3K5, MAP2K4, FBXO18, USP3, LIG4, WRNIP1, RBX1, MSH6, ERN1, MSH2, SMO, POLG2, FANCD2, TIPRL, UBE2V2, TNIK, VCP, INSIG2, INSIG1, FBXO45, FOXO3, RAD51AP1, UBR5, NAE1, CLSPN, MAP2K6, FANCI, UVRAG, GCKR, EIF2B3, HSPA5, UBE2B, FANCL, CAV1, FANCA, FANCC, UBE2A, FANCE, COQ7, MT3, EIF2S1, FBXO31, FANCF, DAP, BCL6, BCL3, JMY, UBE2N, MAP3K10, MAP3K13, FGF12, MAP3K11, MAP3K12, NFE2L2, GSK3B, BMPR2, DYRK2, CEP164, HMGB2, ATP2A1, POLB, DUSP10, EXO1, RB1CC1, CASP3, POLL, POLK, POLH, POLG, RBM14, RFC4, RFC1, GPX4, SH2D3A, RFC2, ARNT, RAD23A, GLRX2, PPP2R5C, SMC1A, SENP2, ETV5, CCNA2, SFPQ, RRM2B, PAPD7, CAT, CRY2, CRY1, ATG4C, DTL, FAN1, PPP1R15B, USP10, PNKP, RNF8, THBS1, UACA, FZR1, POLD2, MAPK1, RBBP7, MUTYH, EYA1, EYA3, SOD2, USP28, PML, KLF2, TICRR, RAD52, EEPD1, RAD51, ERCC3, APC, POLE2, APLF, ERCC2, STUB1, CCM2, ERCC6
80135	Regulation of cellular response to stress	0.025	MECOM, AKT2, UIMC1, MAP3K4, POLH, MAP3K5, NDEL1, MAP4K1, DBNL, RIPK2, AXIN1, MIF, SIRT1, MAPK8IP3, RNF168, ZEB2, NCOR1, TRAF4, UBE2V2, UBE2V1, ZNF675, TLR4, MDFI, CD44, RNF8, NOD1, TNFRSF11A, BRCC3, FOXO1, RTN4, FGD4, PAK1, PRDX1, RPS3, PTK2B, MAP4K5, CD74, GCKR, MAP3K1, EYA1, EIF2AK1, EYA3, SEMA4C, HIPK3, MTOR, HIPK2, FGF19, TAOK2, PDCD4, MDM2, UBE2N, MAP3K10, CD27, ATM, PKN1, ERCC6, MAP3K11, TP73, ATR