Table 1.
Baseline Characteristics of African American DHS-1 Participants Stratified by TTR V122I Carrier Status
| Participants with baseline CMR data | Participants with event follow-up data | |||||
|---|---|---|---|---|---|---|
| Characteristic† | TTR V122I Non-carriers | TTR V122I Carriers | P-value | TTR V122I Non-carriers | TTR V122I Carriers | P-value |
| (N=1,317) | (N=47)* | (N=1,481) | (N=51)** | |||
| Age [years] | 45.1 ± 10 | 44 ± 9.2 | 0.43 | 44.8 ± 10.2 | 45.2 ± 9.4 | 0.89 |
| Female | 752 (57.1) | 28 (59.57) | 0.77 | 898 (60.63) | 33 (64.71) | 0.66 |
| Hypertension | 539 (40.9) | 18 (38.3) | 0.76 | 605 (40.9) | 21 (41.2) | 1 |
| Diabetes Mellitus | 179 (13.6) | 6 (12.8) | 1 | 203 (13.72) | 7 (13.73) | 1 |
| Current Smoking | 419 (31.9) | 17 (36.2) | 0.53 | 447 (30.2) | 18 (35.3) | 0.44 |
| Weight [kg] | 88.8 ± 22.5 | 86.4 ± 23.6 | 0.32 | 90.8 ± 23.7 | 87.7 ± 23.8 | 0.30 |
| Income | 0.45 | 0.57 | ||||
| < 16,000 | 323 (30.3) | 10 (25.6) | 353 (29.3) | 10 (24.4) | ||
| 16,000 - 29,999 | 286 (26.8) | 8 (20.5) | 317 (26.3) | 9 (22) | ||
| 30,000 - 49,999 | 268 (25.1) | 15 (38.5) | 306 (25.4) | 16 (39) | ||
| >= 50,000 | 189 (17.7) | 6 (15.4) | 229 (19) | 6 (14.6) | ||
| Education | 0.71 | 0.80 | ||||
| < High School | 220 (16.7) | 5 (10.6) | 241 (16.3) | 6 (11.8) | ||
| High School | 509 (38.6) | 22 (46.8) | 589 (39.8) | 23 (45.1) | ||
| Some college | 406 (30.8) | 13 (27.7) | 442 (29.8) | 15 (29.4) | ||
| College grad or higher | 182 (13.8) | 7 (14.9) | 209 (14.1) | 7 (13.7) | ||
| Body mass index [kg/m2] | 31.4 ± 7.9 | 30.8 ± 7.6 | 0.52 | 32 ± 8.2 | 31.5 ± 7.8 | 0.62 |
| Systolic blood pressure [mm Hg] | 129.9 ± 20.1 | 129.5 ± 26.2 | 0.25 | 129.5 ± 19.7 | 129.9 ± 26.2 | 0.33 |
| Diastolic blood pressure [mm Hg] | 81 ± 10.7 | 79.8 ± 13.1 | 0.15 | 80.9 ± 10.4 | 79.9 ± 13 | 0.16 |
| Creatinine [mg/dL] | 0.9 (0.8 – 1.0) | 0.9 (0.8 - 1.1) | 0.24 | 0.9 (0.8 - 1) | 0.9 (0.8 - 1.05) | 0.50 |
| eGFR‡ [mL/min] | 102 (88 - 116) | 100 (85 - 110) | 0.23 | 102 (88 - 116) | 101 (85 - 111) | 0.23 |
| NT-proBNP [pg/mL] | 26.1 (10.2 - 58.2) | 23.6 (8.4 - 54.1) | 0.79 | 24.5 (10.1 - 53.9) | 27.8 (12.4 - 59.1) | 0.57 |
| Log-NT-proBNP | 3.22 ± 1.42 | 3.2 ± 1.41 | 0.79 | 3.15 ± 1.37 | 3.31 ± 1.38 | 0.57 |
| hs-cTnT [ng/L] | 1.5 (1.5 - 4.2) | 1.5 (1.5 - 4.0) | 0.56 | 1.5 (1.5 - 3.94) | 1.5 (1.5 - 2.3) | 0.51 |
*
46 individuals are heterozygous and 1 individual is homozygous for the TTR V122I allele.
**
50 individuals are heterozygous and 1 individual is homozygous for the TTR V122I allele.
†
Presented as median [interquartile range] or as mean ± standard deviation for continuous variables where appropriate and N (%) for categorical variables. Groups were compared using Wilcoxon rank-sum test (continuous variables), Fisher exact test (categorical variables), or Cochran-Armitage trend test (ordinal categorical variables: income, education).
‡
eGFR is estimated by the Modification of Diet in Renal Disease equation