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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Card Fail. 2021 Oct 9;28(3):403–414. doi: 10.1016/j.cardfail.2021.09.015

Table 2.

Cardiac Phenotype of African American DHS-1 Participants Stratified by V122I TTR Carrier Status

Non-carriers (N=1,317) Carriers (N=47) Unadjusted Adjusted
Characteristic† No. of people with data Value No. of people with data Value P-value P-value
Cardiac magnetic resonance imaging
LV ejection fraction [%] 1317 0.67 ± 0.07 47 0.66 ± 0.07 0.34 0.28
LV end diastolic volume [mL] 1317 124.6 ± 34.6 47 123.8 ± 30.1 0.99 0.67
LV end diastolic volume by body surface area [ml/m2] 1313 62.19 ± 15.33 47 63.43 ± 16.19 0.85 0.76
LV end systolic volume [mL] 1317 42 ± 23.6 47 42.4 ± 15.6 0.41 0.24
LV end systolic volume by body surface area [ml/m2] 1313 20.93 ± 11.23 47 21.92 ± 9.09 0.55 0.35
Stroke volume [mL] 1317 82.7 ± 17.6 47 81.4 ± 18.4 0.36 0.78
Stroke volume by body surface area [ml/mm2] 1313 41.25 ± 7.33 47 41.51 ± 8.8 0.74 0.83
Myocardial contraction fraction 1317 0.64 ± 0.16 47 0.62 ± 0.15 0.35 0.19
Left atrial volume [mL] 353 71.4 ± 19 13 75.3 ± 25.2 0.72 0.36
Left atrial volume by body surface area [ml/m2] 353 36.19 ± 7.88 13 38.37 ± 8.99 0.27 0.33
LV mass [g] 1317 142.3 ± 44.1 47 144.6 ± 45.3 0.80 0.18
LV mass by body surface area [g/m2] 1313 70.66 ± 18.93 47 73.42 ± 20.15 0.40 0.17
LV wall thickness [mm] 1312 8.21 ± 1.68 44 8.52 ± 1.82 0.51 0.038
LV Concentricity [g/mL] 1317 5.17 ± 0.5 47 5.2 ± 0.51 0.80 0.18
LV hypertrophy by body surface area 1316 230 (17.48) 47 12 (25.53) 0.17 0.14
Electrocardiography
PR interval [ms] 1304 161 ± 23.8 47 159.8 ± 25.3 0.77 0.81
QRS interval [ms] 1314 85.2 ± 11.7 47 84.8 ± 14.7 0.25 0.49
QT interval [ms] 1312 391.4 ± 32.1 47 392.9 ± 31.7 0.49 0.74
LV hypertrophy 1314 217 (16.51) 47 12 (25.53) 0.11 0.13
Limb lead voltage [mm] 1314 28.1 ± 7.9 47 29.5 ± 7.7 0.066 0.18
Sokolow voltage [mm] 1314 24.5 ± 8.3 47 26.3 ± 7.8 0.094 0.13
Total voltage [mm] 1314 1022 ± 255 47 1075 ± 260 0.13 0.14
Limb lead voltage / LV mass [mm*m2/g] 1310 0.41 ± 0.13 47 0.42 ± 0.12 0.39 0.81
Sokolow voltage / LV mass [mm*m2g] 1310 0.36 ± 0.12 47 0.37 ± 0.12 0.28 0.46
Total voltage / LV mass [mm*m2g] 1310 14.9 ± 3.7 47 15.2 ± 3.6 0.35 0.84
*

46 individuals are heterozygous and 1 individual is homozygous for the V122I allele.

†

Presented as mean ± standard deviation for continuous variables and N (%) for categorical variables. Unadjusted p-values were calculated using Wilcoxon rank-sum test (continuous variables) or Fisher exact test (categorical variables). Adjusted p-values were calculated using linear and logistic regression models (for continuous and categorical variables, respectively), including ancestry, age, sex, systolic BP, height and weight as covariates.