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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Card Fail. 2021 Oct 9;28(3):403–414. doi: 10.1016/j.cardfail.2021.09.015

Table 3.

Change in Cardiac Biomarkers, Electrocardiogram, and Cardiac Magnetic Resonance Imaging Parameters from DHS-1 to DHS-2

Non-carriers (N=842) Carriers (N=30)
Characteristic† No. of people with data Value No. of people with data Value Unadjusted P-value Adjusted P-value
Cardiac Biomarkers
ΔNT-proBNP [pg/mL] 834 15.9 (0.0 - 43) 30 28.5 (11.4 – 104.1) 0.034 0.018
Δhs-cTnT [ng/L] 817 3.24 (0 - 6.31) 29 1.33 (0 - 5.81) 0.19 0.32
Cardiac magnetic resonance imaging
ΔLV ejection fraction [%] 586 0.01 (−0.03 - 0.05) 22 0.03 (0 - 0.05) 0.058 0.047
ΔLV end diastolic volume [mL] 586 −1.65 (−11.53 - 7.74) 22 −5.57 (−10.95 - 5.37) 0.70 0.60
ΔLV end systolic volume [mL] 586 −1.43 (−7.03 - 4.16) 22 −4.86 (−9.24 - −1.21) 0.044 0.035
ΔStroke volume [mL] 586 0.13 (−8.4 - 6.43) 22 3.82 (−4.2 - 10.54) 0.18 0.23
ΔLeft atrial volume [mL] 349 2.4 (−10.29 - 12.28) 13 6.04 (−16.2 - 17.8) 0.89 0.76
ΔLV mass [g] 586 −2.65 (−12.3 - 9.2) 22 −0.97 (−4.88 - 6.71) 0.57 0.55
ΔLV wall thickness [mm] 581 0 (−0.55 - 0.59) 22 0.11 (−0.26 - 0.39) 0.54 0.21
ΔLV Concentricity [g/mL] 586 0.43 (−0.13 - 1.04) 22 0.58 (0.25 - 1.01) 0.34 0.29
Electrocardiography
ΔPR interval [ms] 819 4 (−6 - 12) 30 3 (−5.5 - 11) 0.91 0.90
ΔQRS interval [ms] 842 2 (−2 - 6) 30 2 (−2 - 6) 0.66 0.66
ΔQT interval [ms] 841 4 (−16 - 26) 30 6 (−7 - 27.5) 0.40 0.25
ΔLimb lead voltage [mm] 841 3.6 (−0.1 - 7.9) 30 2.6 (0 - 8.6) 0.73 0.32
ΔSokolow voltage [mm] 841 −2.2 (−5.4 - 0.9) 30 −2.3 (−5 - 0.9) 0.74 0.91
Δ Limb lead voltage / LV mass [mm/g] 585 0.06 (0 - 0.15) 22 0.08 (0.01 - 0.16) 0.42 0.34
Δ Sokolow voltage / LV mass [mm/g] 585 −0.02 (−0.07 - 0.03) 22 −0.03 (−0.07 - 0.02) 0.70 0.89
*

1 individual is homozygous for die V122I allele.

†

Presented as median [interquartile range] or as mean ± standard deviation for continuous variables where appropriate and N (%) for categorical variables. Unadjusted p-values were calculated using Wilcoxon rank-sum test. Adjusted p-values were calculated using linear regression models, using the value at DHS-2 as the response variable and adjusted for baseline value, ancestry, age, sex, and systolic blood pressure.