Table 4.

Association of the TTR V122I Carrier Status with Mortality and Cardiovascular outcomes

Outcomes	N event/N Total, non-carriers	N event/N Total, V122I carriers	Hazard Ratio (95% CI)	Unadjusted P-Value	N event/N Total, non-carriers	N event/N Total, V122I carriers	Adjusted Hazard Ratio (95% CI)	Adjusted P-Value
All-cause mortality	183/1481	12/51	1.93 (1.08 - 3.47)	0.027	182/1478	12/51	1.95 (1.08 - 3.51)	0.026
Cardiovascular death	71/1481	6/51	2.49 (1.08 - 5.74)	0.032	70/1478	6/51	2.65 (1.14 - 6.15)	0.023
Atherosclerotic cardiovascular disease	144/1480	7/51	1.4 (0.66 - 2.99)	0.38	144/1477	7/51	1.1 (0.51 - 2.4)	0.8
Heart failure	59/1480	8/51	4.09 (1.95 - 8.56)	<0.001	58/1477	8/51	3.82 (1.8 - 8.13)	<0.001
Myocardial infarction	57/1481	1/51	0.5 (0.07 - 3.62)	0.49	57/1478	1/51	0.43 (0.06 - 3.15)	0.41
Stroke	63/1480	3/51	1.36 (0.43 - 4.35)	0.6	63/1477	3/51	1.11 (0.34 - 3.59)	0.86

^*Hazard ratio for the comparison of carriers of the V122I variant versus non-carriers.

^†Multivariable models are adjusted for baseline age, sex, BMI, systolic blood pressure, eGFR, and 2 principal components of ancestry.

^‡All-cause mortality and cardiovascular death were followed till December 31, 2016 and all other outcomes were followed until December 31, 2013.