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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Am J Med Genet A. 2021 Dec 16;188(4):1056–1064. doi: 10.1002/ajmg.a.62607

Figure 2.

Figure 2.

Adaptive behavior scores at baseline and 1-year follow-up in individuals with CLN3-related disorders. A. Cross-sectional relationship (baseline only) of Vineland-3 adaptive behavior composite and domain scores to age (n=20, excluding vision-only participants). Line: fitted curve for CLN3. Circles: individual data points. Shaded area: 95% CI. B. Model-estimated mean within-subject change over 1-year follow-up in Vineland-3 domain (standard) and subdomain (V-scale) scores (n=15, excluding vision-only participants). ABC: adaptive behavior composite. C. Within-subject change over 1-year follow-up in Vineland-3 growth scale values in CLN3 disease (n=15, excluding vision-only participants). Change scores were compared to the manual-based average SEM for each subdomain, and values that exceeded 2*SEM are shaded pink. D. Model-estimated mean within-subject change over 1-year follow-up in Vineland-3 growth scale values in CLN3 disease (n=15, excluding vision-only participants). Score of zero represents no change in ability; negative scores indicate a decrease in ability.