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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Bioorg Chem. 2022 Feb 8;121:105660. doi: 10.1016/j.bioorg.2022.105660

Scheme 1.

Scheme 1.

(a) for 13: Mg, Br(CH2)3CH(CH3)2, THF, 0 °C → rt, 85%; for 14: Mg, Br(CH2)3C(CH3)2OTES, THF, 0 °C → rt, 80%; (b) TPAP, NMO, 4 Å MS, CH2Cl2, 0 °C → rt, 15: 77%, 16: 80%; (c) TMSOTf, 2,6-lutidine, CH2Cl2, −78 °C, 17: 84%, 18: 82%; (d) 9, n-BuLi, THF, −78 °C, 19: 81%, 20: 91%; (d) TBAF, THF, rt, 3: 84%, 6: 75%.