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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Bioorg Chem. 2022 Feb 8;121:105660. doi: 10.1016/j.bioorg.2022.105660

Figure 3.

Figure 3.

Inhibition of cell proliferation by 20S(OH)D3, 20S,25(OH)2D3, 20S,23S(OH)2D3 and 20S,23R(OH)2D3 in comparison to 1α,25(OH)2D3. Human epidermal (HaCaT) keratinocytes (A, C) or dermal fibroblasts (B, D) were treated for 24 h (1) or 48 h (2) with graded concentrations of the compounds: 0.1, 1, 10, or 100 nM. Ethanol (0.1%) served as a negative control. Data are means ± SD (n = 6) and were analyzed using Student’s t-test with p < 0.05 (*), p < 0.01 (**) or p < 0.001 (***).