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. 2022 Mar 15;24(3):299–306. doi: 10.1038/s41556-022-00852-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, Northern blot analysis shows no differences in the levels of precursor and mature tRNA-Tyr (GUA) in PUS7-KD MDS-L ± mTOG-Ψ (left) and CD34- MNC from two aged-matched HC and HR-MDS patients (bottom right). U6 RNA is included as a loading control. Data represent n=3 independent experiments for MDS-L, except when n=1 due to limited patient material availability. b, Representative FACS analysis shows increase immature MDS propagating cells (CD34⁺/CD45RA⁺/CD123⁺) in PUS7-KD MDS-L compared to controls. Graph shows % of CD34⁺/CD45RA⁺/CD123⁺ cells in CTRL and PUS7-KD MDS-L lines. n=5 independent biological replicates, ****p<0.0001 (two-sided t test). Data is shown as mean ± SD.

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