Extended Data Fig. 10. mTOG-Ψ does not affect LR-MDS HSPC engraftment and multi-lineage differentiation.
a, Representative FACS plots illustrates hCD45 expression in the BM of NSG-S mice untransplanted and transplanted with LR-MDS HSPC ± mTOG-Ψ. Graphs show FC human engraftment to SCR-Ψ-treated mice in 8 weeks post-transplantation (n=3 mice). ns, no statistical significance (two-sided t test). b, FACS plot shows the expression of myeloid (CD33) and B cell (CD19) markers in the BM of transplanted mice. Graph shows FC lymphoid (CD19+) cells to SCR-Ψ in individual mice transplanted with LR-MDS HSPC ± mTOG-Ψ. ns, no statistical significance (two-sided t test). Dots represent individual mice (n=3 mice) transplanted with cells from two LR-MDS patient samples. Data is shown as mean ± SD.