Table 2.

Routine interferents that can impact biomarker assays^*.

Common endogenous interferents	Interferent concentrations to test	Examples of causes of high interferent concentrations	Examples of assays impacted by interferent
Hemolysate (Hemoglobin)	0 - 500 mg/dL	hemolysis	Potassium, aspartate transaminase (AST), amylase, calcium, phosphorus, magnesium, total protein, and total and direct bilirubin
Triglycerides	0 - 1000 mg/dL (CLSI recommendation 3000 mg/dL)	hyperlipemia	phosphorus, creatinine, total protein, calcium, hemoglobin
Total Protein (from Albumin and gamma-globulins)	0 - 12 g/dL	dehydration, multiple myeloma	carbon dioxide, apolipoprotein AI, and apolipoprotein B
Bilirubin, conjugated	0 - 20 mg/dL	hemolysis, gall bladder disease	Creatinine, total protein and assays that use a peroxidase as the detection system
Bilirubin unconjugated	0 - 20 mg/dL	liver disease	assays that use a peroxidase as the detection system

^*modified from information available online from Sun Diagnostics (https://sundiagnostics.us/assurance/); CLSI, Clinical and Laboratory Standards Institute