Table 1.
The role of LINC00520 in various cancers.
| Tumor type | Number of clinical samples | Assessed cell line | The expression of LINC00520 | Effect in vivo | Effect in vitro | Regulatory mechanism | Ref. |
|---|---|---|---|---|---|---|---|
| Lung cancer | 52 paired tissues | H460, H1975, H1299, A549, and BEAS-2B | Up-regulation | — | migration↑, invasion↑, proliferation↑, cell cycle↑, apoptosis↓ | LINC00520/miR-3175 | (11) |
| BC | MCF10A, SKBR3, MCF7, MDA-MB-468, MDA-MB-453, MDA-MB-231, T47D, BT549, and SUM159-PT | Up-regulation | — | migration↑, invasion↑ | STAT3 promote LINC00520 | (8) | |
| PI3K signaling pathway promote LINC00520 | |||||||
| 504 cases with BC and 505 healthy controls | 293T | Up-regulation | — | LINC00520/miR-3122 | (4) | ||
| PTC | 59 paired tissues | HT-ori3, HTH83, K-1, BCPAP, and TPC-1 | Up-regulation | tumor growth ↑ | migration↑, invasion↑, apoptosis↓ | LINC00520/miR-577/Sphk2 | (14) |
| CRC | 132 paired tissues | NCM460, HCT116, SW480, HT29, and Lovo | Up-regulation | — | colony forming ability↑, migration↑, invasion↑, proliferation↑, apoptosis↓ | LINC00520/miR-577/HSP27 | (15) |
| cSCC | A431 | De-regulation | tumor growth ↓ | migration↓, invasion↓, proliferation↓, adhesion↓ | LINC00520/EGFR/PI3K/AKT | (22) | |
| MM | Up-regulation | — | (18) | ||||
| Up-regulation | EMT↑ | LINC00520/let-7a-5p/DTL | (17) | ||||
| 41 paired tissues | A375, A2058, MeWo, CHL-1, and SK-MEL-28 | Up-regulation | tumor growth ↑ pro-metastasis | migration↑, invasion↑, proliferation↑, EMT↑ | LINC00520/miR-125b-5p/EIF5A2 | (16) | |
| activity ↑ | |||||||
| LUAD | 20 paired tissues | A549, H1975, H2030, H1435, and BEAS-2B | Up-regulation | — | migration↑, invasion↑ | LINC00520/miR-3611/FOXP3 | (13) |
| 30 paired tissues | A549, H358, H1299, and HBE | Up-regulation | tumor growth ↑ | migration↑, invasion↑, proliferation↑ | LINC00520/miR-1252-5p/FOXR2 | (12) | |
| HNSCC | 40 paired tissues | SCC-25, PCI-37B, TU686, and TE-10 | Up-regulation | tumor growth ↑ | migration↑, invasion↑, proliferation↑, apoptosis↓ | LINC00520/miR-195/HOXA10 | (19) |
| LSCC | 65 paired tissues | Up-regulation | — | (20) | |||
| glioma | 12 cases with grade I‐II, 12 cases with grade III‐IV, and 12 health controls | U87, U251, and HEK293 | Up-regulation | tumor growth ↑ | migration↑, invasion↑, proliferation↑, apoptosis↓ | TFAP4/LINC00520/miR-520f-3p | (9) |
| NPC | 50 paired tissues | SUNE-1, CNE-1, HNE-1, CNE-2, C666-1, HONE-1, and NP69 | Up-regulation | tumor growth ↑ | proliferation↑ | LINC00520/miR-26b-3p/USP39 | (21) |
| NSCLC | 150 paired tissues | H1975, H1299, PC 9, HCC827, A549, and BEAS-2B | Up-regulation | tumor growth ↑ | migration↑, invasion↑, proliferation↑, apoptosis↓ | LINC00520/miR-577/CCNE2 | (10) |
| EMT↑ |
BC, breast cancer; PTC, papillary thyroid carcinoma; CRC, colorectal cancer; cSCC, cutaneous squamous cell carcinoma; MM, melanoma; LUAD, lung adenocarcinoma; HNSCC, head and neck squamous cell carcinoma; LSCC, laryngeal squamous cell carcinoma; NPC, nasopharyngeal carcinoma; NSCLC, non-small cell lung cancer; EMT, epithelial-mesenchymal transition.