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. 2022 Mar 2;13:834329. doi: 10.3389/fneur.2022.834329

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Copyright © 2022 Yang, Li, Zhan, Feng, Lu, Li, Zhuang, Lei and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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pMCAO caused cognitive decline in rats. (A–C) Representative swimming traces of the sham and pMCAO rats in the training trial, probe trial, and platform switched trial, respectively. (D,E) Quantitative data of the escape latency and path length of rats spent to locate the submerged platform during the training trial. (F) Quantitative analysis of the percentage time and path length of rats spent in the original quadrant in the probe trial. (G,H) Quantitative analysis of the escape latency and path length of rats taken to find the switched platform during the platform switched trial (Two-way repeated measures ANOVA with between subject factor-surgery and within subject factor-time for (D) and (E). Student's t-test for (F–H). N = 8 for the sham group and N = 9 for the pMCAO group). ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. sham group.