TABLE 3.
Multidrug-resistant isolates of M. tuberculosis treated with melatonin and INHa
| Concn of melatonin (mM) | % Growth inhibition of multidrug-resistant isolates with INH at a concn (μg/ml) of:
|
||||||
|---|---|---|---|---|---|---|---|
| 0.0 | 0.025 | 0.05 | 0.5 | 10.0 | 20.0 | 40.0 | |
| 0 | 0.0 | 0.0 | 0.0 | 0.0 | 20.0 | 47.5 | 100.0 |
| 0.01 | 13.0 | 0.0 | 0.0 | 7.5 | 49.5 | 57.0 | |
| 0.1 | 17.0 | 11.0 | 15.0 | 8.0 | 41.0 | 67.5 | |
| 0.2 | 24.8 | 23.0 | 33.0 | 33.0 | 52.0 | 70.5 | |
| 0.4 | 37.5 | 40.5 | 41.0 | 40.0 | 57.0 | 79.5 | |
| 0.8 | 57.8 | 60.0 | 53.5 | 60.5 | 72.0 | 94.0 | |
| 1.0 | 54.0 | 67.0 | |||||
| 2.0 | 70.5 | 70.5 | |||||
| 4.0 | 85.0 | 79.5 | |||||
| 8.0 | 98.2 | 94.0 | |||||
| 10.0 | 99.2 | ||||||
a
Two multidrug-resistant M. tuberculosis patient isolates were treated with melatonin and INH, and the results were averaged. Both strains were resistant to INH (20 and 40 μg/ml) and rifampin and were classified catalase negative (19 and 0 mm).