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. 2022 Mar 15;12:4394. doi: 10.1038/s41598-022-08528-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental protocol and histological verification. (A) Schematic representation of the study timeline. Animals received bilateral i.c.v injection of saline or Aβ 4 μg in 2 μl. After recovery from surgery and model induction, animals were placed in the open field for habituation at day 26 and NOR task, with one day apart. (B) 3D view of electrode implantation sites on the brain and histological confirmation. i.c.v, intracerebroventricular; Aβ amyloid-beta, NOR novel object recognition, OB olfactory bulb, dHPC dorsal hippocampus, EC entorhinal cortex.