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. 2022 Mar 15;12:4394. doi: 10.1038/s41598-022-08528-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Survived cells in the OB. (A and B) Schematic representation of OB subregions. (C) a sample of immunostaining sections from OB of animals that received i.c.v. saline and Aβ. (D) Immunostaining of anti-Aβ_1-42 indicated a high level of plaque accumulation in Aβ animals compared to the saline group. (E) Representative of OB section stained by Nissl method to evaluate the survived cells in OB subregions. (F) Aβ animals demonstrate significantly lower survival cells in this region compared to the saline group. Red arrows show dense bodies of dead cells. Aβ amyloid-beta, OB olfactory bulb, GCL granule cell layer, GLM glomerular layer, EPL external plexiform layer, MCL mitral cell layer, SUB subependymal layer, *p < 0.05, **p < 0.01, ***p < 0.001 compared to saline. #p < 0.05, ##p < 0.01, ###p < 0.001 comparision among OB subregions in Aβ group.