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. 2022 Mar 15;12:4394. doi: 10.1038/s41598-022-08528-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Aβ animals showed recognition memory impairment. (Left) Top panels indicate tracking points during the NOR task. The bottom panels denote that the preference ratio for the novel object was significantly attenuated in Aβ animals, measured by discrimination index, percentage by time spent, and mean of time spent. (Right) Aβ and saline animals showed no significant differences in the total traveled distance as an indicator of locomotor activity. Bar graphs represent mean ± SEM. The comparison was conducted by t-test, n = 6 per group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 Aβ compared to saline. Aβ amyloid-beta, F familiar object, N novel object, NOR novel object recognition.