Fig. 7. Effect of age on the quantity of naïve lymphocyte subsets.
a, b Percent of naïve B cells on total B lymphocytes (a, each dot represents a single donor and lines the median) and their correlation (b) with HPV-6, HPV-11, HPV-16 and HPV-18-specific IgG titers (regression lines and their equations are shown); n = 28 (14 adolescents and 14 adults). c, d Percent of naïve CD4+ T cells on total CD4+ T lymphocytes (c, each dot represents a single donor and lines the median) and their correlation (d) with HPV-6, HPV-11, HPV-16, and HPV-18-specific IgG titers (regression lines and their equations are shown); n = 24 (14 adolescents and 10 adults). Samples are from the “Early cohort”. Statistical significance was determined by the Mann–Whitney test and Spearman’s rank correlation and all p-values are shown.