Table 1.
Clinical and MRI characteristics of all patients. Abbreviations include expanded disability status score (EDSS), symbol digit modality test (SDMT), California verbal learning test-II (CVLT-II), and brief visuospatial memory test-revised (BVMT-R). Thalamic volume is unitless (normalized to head size). Significant values are in bold.
| Characteristics | Patients with zero rim+ lesions (n = 102) | Patients with at least one rim + lesion (n = 57) | p-value |
|---|---|---|---|
| Female, n (%) | 76 (74.51) | 39 (68.42) | 0.523 |
| Disease duration (years), mean (SD) | 11.02 (8.05) | 10.24 (7.37) | 0.528 |
| Age (years), mean (SD) | 41.96 (17.58) | 42.54 (10.14) | 0.731 |
| Current treatment duration, mean (SD) | 3.80 (4.28) | 2.88 (3.32) | 0.131 |
| Cognitive score, mean (SD) | |||
| SDMT | 58.31 (11.14) | 52.70 (11.78) | 0.004 |
| CVLT-II | 54.34 (8.42) | 50.86 (11.95) | 0.028 |
| BVMT-R | 25.27 (5.93) | 22.88 (7.57) | 0.032 |
| Cognitive impairment, n (%) | |||
| SDMT | 15 (14.71) | 20 (35.09) | 0.005 |
| CVLT-II | 6 (5.88) | 10 (17.54) | 0.038 |
| BVMT-R | 21 (20.59) | 20 (35.09) | 0.069 |
| EDSS, median (IQR) | 0.5 (2) | 1.50 (2.5) | 0.025 |
| MRI measures | |||
| Cortical thickness (mm), mean (SD) | 2.53 (0.09) | 2.48 (0.09) | 0.002 |
| Thalamic volume, mean (SD) | 0.0093 (0.0009) | 0.0089 (0.0008) | 0.0051 |
| No. lesions on FLAIR, median (IQR) | 13 (20) | 34 (31) | < 0.001 |
| Lesion volume on FLAIR (mm3), mean (SD) | 3127.72 (4619.32) | 10,296.04 (10,412.46) | < 0.001 |