Table 2.
Summary of p-values from the Multivariate Analysis of Variance (MANOVA) table and subsequent Analysis of Variance (ANOVA) tables for each score. The final multivariate model for SDMT, CVLT-II, BVMT-R, and EDSS as vectors of response variables included current Treatment Duration, Age, Gender, No. RIM of + lesions, log T2wFLAIR lesion volume, and the interaction term No. RIM * logT2wFLAIR.lesion.volume as covariates. This report gives the p-values associated with the MANOVA Pillai test and the approximated F-statistics for each score (ANOVA). The bolded values represent the significant association of the interaction term (No. RIM * logT2wFLAIR.lesion.volume) with the clinical outcomes.
| MANOVA | ANOVA for each cognitive score | ||||
|---|---|---|---|---|---|
| SDMT | CVLT-II | BVMT-R | EDSS | ||
| (Intercept) | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.386 |
| Current treatment duration | 0.012 | 0.389 | 0.137 | 0.513 | 0.009 |
| Age | < 0.001 | < 0.001 | 0.030 | < 0.001 | < 0.001 |
| Gender | 0.038 | 0.508 | 0.003 | 0.592 | 0.841 |
| No. RIM (0 rim + versus 1 + rim + lesion) | 0.010 | 0.011 | 0.050 | 0.157 | 0.001 |
| logT2wFLAIR.lesion.volume | < 0.001 | < 0.001 | 0.294 | 0.002 | 0.607 |
| No. RIM * logT2wFLAIR.lesion.volume | 0.006 | 0.010 | 0.030 | 0.165 | 0.001 |