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. 2022 Mar 15;8:117. doi: 10.1038/s41420-022-00923-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Mouse cytokine array C-1000 was used to detect chemokine variations in the supernatants of K7M2 cells treated with DMSO or JQ-1, n = 3. B Statistical results of grayscale analysis, chemokines with a fold change >2 and P < 0.05 are shown. C Representative immunohistochemical images of CXCL9, CXCL10, and CCL5 in K7M2 tumors, treated with JQ-1 or DMSO (400×, scale bar: 100 μm). D, E Representative bioluminescence pictures of mice on day 28 after injection of chemokine neutralizing antibody, tumor burdens were evaluated by total flux, n = 6. F The long-term survival of mice treated with CXCL9, CXCL10, CCL5 neutralizing antibody. G Correlation analysis of c-Myc expression and CXCL9, CXCL10, CCL5 expression in human samples (GEO dataset). H The relationship between the expression of CXCL9, CXCL10, and CCL5 and the prognosis of osteosarcoma (TARGET database).