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. 2022 Mar 15;13:1346. doi: 10.1038/s41467-022-28962-w

Fig. 9. Schematic of myosin VI anchoring RNAPII at transcription factories.

Fig. 9

Based on the data presented here we can propose this model for RNAPII clustering. Transcription sites within the nucleus are marked by clustering of RNAPII and actin filaments. Focusing on the clusters: The protein rich core consists of transcription regulators which the DNA would also contact. MVI interacts with these proteins and DNA via its C-terminal domain. MVI then interacts with RNAPII through nuclear actin filaments thereby providing the framework for mechanical linkage to RNAPII.