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. 2022 Mar 15;13:1365. doi: 10.1038/s41467-022-28974-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative inverted fluorescent images of N2A-P1KO transfected with GFP vector in control medium (left), GFP, PIEZO2 (middle) or IDR5^del (right) in medium without serum and with nerve growth factor (NGF). b Representation of the longest neurite measured (in µm) per cell for GFP in control medium and GFP (gray), PIEZO2 (black) and IDR5^del (blue) in medium without serum and with NGF. Comparison with Kruskal–Wallis test, p < 0.0001, and Dunn’s post-test: GFP control vs. GFP + NGF w/o serum (P < 1e−15), GFP + NGF w/o serum vs. PIEZO2 (P < 1e−15), PIEZO2 vs. IDR5^del (P < 1e−15). Symbols are individual cells, with red line being the median. N-number of cells per group is: GFP control (N = 343), GFP (N = 743), PIEZO2 (N = 733), IDR5^del (N = 685). c Cumulative distribution of the number of neurites per cell across GFP control, GFP, PIEZO2 and IDR5^del group. Total number of cells per group is: GFP control (N = 836), GFP (N = 854), PIEZO2 (N = 998), IDR5^del (N = 810). Source data are provided as a Source Data file.