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. 2022 Mar 2;9:800152. doi: 10.3389/fmolb.2022.800152

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Copyright © 2022 Stoll, Naldi, Noël, Viara, Barillot, Kroemer, Thieffry and Calzone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simple cell differentiation model. (A) Definition of the toy model with logical rules (upper panel) and conditional rule for R depending on the value of the external parameter innerOn. If innerOn is equal to 1, then A is able to activate L in all cells (middle panel). If innerOn is set to 0, then the value of R will depend on the population status of L (lower panel). (B) Model simulations of the two cases: when innerOn = 1, only T1 cell type can be reached; when innerOn = 0, a proportion of cells can differentiate into T2 cell type.