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. 2022 Mar 2;9:800152. doi: 10.3389/fmolb.2022.800152

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Copyright © 2022 Stoll, Naldi, Noël, Viara, Barillot, Kroemer, Thieffry and Calzone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell fate model for TNFα resistance. (A) This model is an extension of the model reported in (Calzone et al., 2010). Some nodes representing the mRNA of cIAP, ROS and XIAP family members have been added. The ellipsoid nodes represent genes, mRNA, proteins, or complexes, while the rectangular nodes denote phenotypes. Green and red arrows represent positive and negative influences, respectively. The thick green arrows denote activating interactions added to the initial model: a feedback from NFκB to TNFα encodes the ligand-receptor activation, while the “Division” and “Death” nodes have been introduced specifically for UPMaBoSS population updates. (B) Simulation of the cell fate model with MaBoSS for 48 h. (C) Simulation of the model with UPMaBoSS: temporal evolution of population sizes with (black) and without (blue) the TNF paracrine signaling.