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ZDQ-0620 inhibits PI3K target activity. (A) Predicted binding modes for ZDQ-0620 with PI3Kα (PDB code: 4JPS). (B–E) A cellular thermal shift assay (CETSA) and an isothermal dose-response fingerprinting (ITDRF)cetsa were used to evaluate the thermal stability of ZDQ-0620 bound to PI3Kα/β.
