Figure 6.

ZDQv-0620 inhibits the migration, invasion and interaction. (A, C) Cell migratory ability was tested using a wound healing assay; scale bar, 50 μm. (B, D) Cell invasiveness was assessed using a Transwell assay with Matrigel; scale bar, 50 μm. (E) HUVECs were inoculated alone in the upper chamber or co-cultured with HCT116 cells in the lower chamber with or without ZDQ-0620 (2uM) for comparison, Scale bar =100 µm. (F) HCT116 was inoculated alone in the upper chamber or co-cultured with HUVECs cells in the lower chamber with or without ZDQ-0620 (2uM) for comparison. A histogram of the invaded and migrated rates is shown at the bottom. Each value is the mean (± SD) from triplicate samples; *p < 0.05, **p < 0.01, ***p < 0.001 vs. the control. One-way analysis of variance followed by Tukey’s post hoc multiple-comparisons test.